Tissue factor expression in normal and abnormal mammary gland
نویسندگان
چکیده
منابع مشابه
Expression of the Pluripotency Transcription Factor OCT4 in the Normal and Aberrant Mammary Gland
Breast cancers with lactating features, some of which are associated with pregnancy and lactation, are often poorly differentiated, lack estrogen receptor, progesterone receptor, and HER2 expression and have high mortality. Very little is known about the molecular mechanisms that drive uncontrolled cell proliferation in these tumors and confer lactating features. We have recently reported expre...
متن کاملDifferential expression of human tissue factor in normal mammary epithelial cells and in carcinomas.
BACKGROUND Tissue factor (TF) is a glycoprotein which binds factor VIIa. The TF-VIIa complex serves as a potent initiator of the coagulation pathways. TF, an immediate early gene, may also play a role in cell growth. Expression of TF was correlated with some types of cancers. MATERIALS AND METHODS Normal, immortalized, and tumor human mammary epithelial cells were used in the experiments. The...
متن کاملExpression of prolactin receptors in normal canine mammary tissue, canine mammary adenomas and mammary adenocarcinomas
BACKGROUND Mammary tumors represent the most common neoplastic disease in female dogs. Recently, the promoting role of prolactin (PRL) in the development of human breast carcinoma has been shown. Possible proliferative, anti-apoptotic, migratory and angiogenic effects of PRL on human mammary cancer cells in vitro and in vivo were suggested. The effects of PRL are mediated by its receptor, and a...
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In this paper we present a scheme for real time segmentation of histological structures in microscopic images of normal and neoplastic mammary gland sections. Paraffin embedded or frozen tissue blocks are sliced, and sections are stained with hematoxylin and eosin (H&E). The sections are then imaged using conventional bright field microscopy. The background of the images is corrected by arithme...
متن کاملInterleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes.
Although prolactin and interleukin 2 (IL-2) can elicit distinct physiological responses, we have found that their signal pathways share a common signal transducer and activator of transcription, STAT5. STAT5 was originally identified as a mammary gland factor induced by prolactin in lactating breast cells. Here we demonstrate that STAT5 is activated after IL-2 stimulation of two responsive lymp...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 1996
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm0596-491a